INNOVATIONS IN VACCINE DEVELOPMENT: WHAT NEXT?

Accelerating next-generation vaccine development for global disease prevention.

Vaccines are among the greatest successes in the history of public health. However, past strategies for vaccine development are unlikely to succeed in the future against major global diseases such as AIDS, tuberculosis, and malaria. For such diseases, the correlates of protection are poorly defined and the pathogens evade immune detection and/or exhibit extensive genetic variability. Recent adv...

Perspectives in HIV Vaccine Development: What we have Learned and

Thirty years have passed since the first report of Acquired Immunodeficiency Syndrome (AIDS) and the subsequent discovery of its etiological agent, the human immunodeficiency virus (HIV) [1,2]. Never before has a single virus been so thoroughly studied, providing vast amounts of data and insight into the intricate complexities of its innate and adaptive immune responses. Despite this knowledge ...

What should we do next for MT system development?

Machine translation (MT) research and development began at the end of 1950’s when not only natural language processing (NLP) technology but also linguistic theory was at a primitive level. Given the restricted memory sizes and computing power at that time, MT presented one of the most difficult and challenging research themes of the day. Thus. MT researchers and developers were forgiven when th...

What next in necrotizing enterocolitis?

Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, with a mortality rate of 10-50%. It is uncommon in term infants and in premature infants who have not yet been fed. Most commonly NEC develops suddenly in a preterm infant who was otherwise well, with initial symptoms of abdominal distention, bilious or bloody emesis or gastric aspirates, hematochezia, and pneumatosi...

where do we stand and what comes next?